Connection problems are usually related to the USB cable from the controller to Titan Two. It can also be a power issue (add a power supply).
Titan Two's processing loop runs at sub-1ms. Input and Output polling can sync perfectly with XIM APEX at all Response Rates.
Despite being capable of polling at 1ms, the best a Zen processing loop can perform is 4.5ms, which will max out the CPU and cause input lag. All of their Gamepacks run at 10ms, which adds lag to XIM input and can cause USB desync.
Running Zen at 4ms polling (250Hz) should prevent USB desync, but there's still an internal desync with the processing loop.